Drug intermediates
Alprostadil Prostaglandins E1 Pge1 CAS 745-65-3
English name: Prostaglandin E1 CAS Number: 745-65-3 Molecular formula: C20H34O5 Molecular weight: 354.49 EINECS number: 212-017-2 Prostaglandin E1 (ProstaglandinE1) is also known as alprostadil, Baodaxin, Kaishi and Kaiweijie. Prostaglandin E1 is a biologically active substance widely present in the body, a member of the prostaglandin family, and a recognized endogenous physiologically active substance. Prostaglandin E1 acts directly on vascular smooth muscle, dilates blood vessels, increases blood flow, and improves microcirculation perfusion; and inhibits platelet aggregation and thromboxane A2 production, inhibits atherosclerosis, lipid plaques and immune complex formation; dilates peripheral small blood vessels and coronary artery, reduce peripheral vascular resistance and blood pressure, protect platelet cell membrane, prevent thrombosis; protect ischemic myocardium, reduce myocardial infarction size; resist heart failure; dilate renal blood vessels, increase renal blood flow, remove non-protein nitrogen, and regulate water and sodium Balanced, has a diuretic and renal function-protecting effect. t1/2 is 5¡«10min. 68% is excreted by the kidney after being metabolized by the liver. Clinically used for coronary heart disease angina pectoris, myocardial infarction, pulmonary hypertension, chronic arterial occlusion, etc.
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